Matthijs van der Meer
The van der Meer lab studies the interplay between learning, memory, and prediction in rodents performing decision tasks. We record and decode the activity of many neurons simultaneously during behavior to reveal the neural representations and transformations that underlie cognitive processes such as deliberation, inference, and planning. Through a combination of neurobiological and computational approaches, we seek a fundamental understanding of these processes at the level of neural circuits, within and across interacting brain areas such as the hippocampus, striatum, and frontal cortex. We believe that in the long term, this understanding can support sustained innovation in the prevention and treatment of disorders such as addiction and obsessive-compulsive disorder.
Works in Progress
What factors determine the content of hippocampal replay?
How do hippocampal sequences relate to behavior in complex environments?
What is the role of oscillations in routing the flow of information in cortico-hippocampal-striatal circuits?
Selected Works and Activities
van der Meer MA, Ito R, Lansink CS, Pennartz CMA (2014) Hippocampal projections to the ventral striatum: from spatial memory to motivated behavior. In: "Space, Time & Memory in the Hippocampal Formation" (Knierim JJ and Derdikman D, eds.), Springer.
Caze R, van der Meer MA (2013) Adaptive properties of differential learning rates for positive and negative outcomes. Biological Cybernetics 107(6): 711-719.
van der Meer MA, Kurth-Nelson Z, Redish AD (2012) Information processing in decision-making systems. The Neuroscientist 18 (4): 342-359.
Gupta AS, van der Meer MA, Touretzky DS, Redish AD (2012) Segmentation of spatial experience by hippocampal theta sequences. Nature Neuroscience 15: 1032-1039.
van der Meer MA, Redish AD (2011) Theta phase precession in rat ventral striatum links place and reward information. Journal of Neuroscience 31(8): 2843-2854.
van der Meer MA, Johnson A, Schmitzer-Torbert NC, Redish AD (2010) Triple dissociation of information processing in dorsal striatum, ventral striatum, and hippocampus on a learned spatial decision task. Neuron 67(1): 25-32.
Gupta AS, van der Meer MA, Touretzky DS, Redish AD (2010) Hippocampal replay is not a simple function of experience. Neuron 65(5): 695-705.